Comparative activities of tigecycline and other tetracyclines against nonfermenting Gram-negative bacilli, excluding Acinetobacter spp.

Tigecycline, a glycylcycline, is a semisynthetic derivative of minocycline with a broad spectrum of activity against aerobic and anaerobic bacteria (2, 12, 16). In the literature there are several publications concerning tigecycline activity, most of them related to Acinetobacter baumannii and Stenotrophomonas maltophilia isolates (1, 5, 8, 10, 11, 14); however, its activity against other species of nonfermenting Gram-negative bacilli (NFGNB) has rarely been reported. Here we determined the activities of tetracycline, doxycycline, minocycline, and tigecycline against 195 clinical isolates of NFGNB (excluding Acinetobacter spp.) recovered from clinical materials of patients treated at the Hospital de Clínicas Jose de San Martin, Universidad de Buenos Aires, Argentina,